Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelia

Airway epithelial cells in cystic fibrosis (CF) overexpress Interleukin 8 (CXCL8) through poorly defined mechanisms. CXCL8 transcription is dependent on coordinated binding of CCAAT/enhancer binding protein (C/EBP)β, nuclear factor (NF)-κB, and activator protein (AP)-1 to the promoter.

Researcher: Anna Poghosyan

This research was published in Biochemical and Biophysical Research Communications in August 2016:

http://www.sciencedirect.com/science/article/pii/S0006291X16308622

#LabResearch