CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma
Updated: Jun 10, 2019
Asthma is characterized by airway inflammation and remodeling and CXCL8 is a CXC chemokine that drives steroid-resistant neutrophilic airway inflammation. We have shown that airway smooth muscle (ASM) cells isolated from asthmatic individuals secrete more CXCL8 than cells from nonasthmatic individuals. Here we investigated chromatin modifications at the CXCL8 promoter in ASM cells from nonasthmatic and asthmatic donors to further understand how CXCL8 is dysregulated in asthma.
Researcher: Dr Rachel Clifford
This research was published in the American Journal of Physiology in May 2015: