Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ
Updated: Jun 10, 2019
Caffeine is a commonly used food additive found naturally in many products. In addition to potently stimulating the central nervous system caffeine is able to affect various systems within the body including the cardiovascular and respiratory systems. Importantly, caffeine is used clinically to treat apnoea and bronchopulmonary dysplasia in premature babies. Recently, caffeine has been shown to exhibit antifibrotic effects in the liver in part through reducing collagen expression and deposition, and reducing expression of the profibrotic cytokine TGFβ.
Researcher: Dr Amanda Tatler
This research was published in BMJ Thorax in June 2016: